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    黄展鹏

    医疗/科研特长

    中山大学附属第一医院研究员、博导。博士毕业于中山大学;曾在哈佛医学院波士顿儿童医院任讲师及进行博士后研究。2017年通过中山大学“百人”计划引进到中山大学附属第一医院。长期从事心血管发育与疾病的分子机制研究,主要从分子、细胞、小鼠模型以及病人多个层面研究蛋白质基因网络和非编码RNA基因网络如何协同调控心血管疾病的发生发展,并以探索新的心血管疾病基因疗法为最终目标。在JCI、Circulation Research、Circulation等医学及心血管一区期刊中发表论文近三十余篇,其中包括4篇ESI高被引用论文,发表论文被引用超过1600次。主持国家自然科学基金委面上项目1项,广东省自然科学基金杰出青年项目,广东省国际科技合作领域项目1项,美国心脏协会(AHA)项目2项。曾获得美国国立卫生研究院的Ruth L. Kirschstein国家研究奖及美国心脏协会心血管基础科学大会的New Investigator award,以及广东省医学杰出青年医学人才称号

     

    研究方向:

    1, 心脏疾病发病机理及防治的研究

    1)研究新的调控因子CIP在心脏病变中的分子调控机制和转化应用;

    2)鉴定与研究心脏病变中重要的靶标长链非编码RNA及其对疾病的调控功能;

    3)研究microRNA在心脏病变中对心肌细胞生长、凋亡及代谢的调控作用。

    2, 先天性心血管疾病发病机理及预警的研究

    1)研究microRNA对先天性心血管疾病发病的调控;

    2)探讨人类先天性心血管疾病与microRNA基因突变的相关性及临床转化;

     

    主要教育和工作经历:

    2017/11-至今,中山大学附属第一医院,转化医学研究中心,研究员

    2018/11-至今,国家卫健委辅助循环研究重点实验室,副主任

    2010/10-2017/11,美国哈佛医学院,波士顿儿童医院,心脏病科,讲师

    2009/8-2010/10,美国哈佛医学院,波士顿儿童医院,心脏病科,博士后研究助理( 合作导师:Dr. Da-Zhi Wang)

    2008/2-2009/7,美国北卡罗来纳州大学教皇山分校,卡罗来纳心血管生物学中心,博士后研究助理(合作导师:Dr. Da-Zhi Wang)


    社会兼职:

       广东省精准医学应用学会疾病模型分会会员

     

    论著:

    1.      Huang ZP, Wang DZ. miR-22 in Smooth Muscle Cells: A Potential Therapy for Cardiovascular Disease. Circulation. 2018 Apr 24;137(17):1842-1845. doi:10.1161/CIRCULATIONAHA.118.033042.Circulation (2018SCI影响因子:23.054)

    2.      Huang, Z.P., Ding Y., Kataoka, M., Hu Y.W., dos Remedios C.G., Pu W.T. and Wang D.Z. Long non-coding RNAs link extracellular matrix gene expression to ischemic cardiomyopathy. Cardiovascular research. 2016, 112: 543-554. (2018SCI影响因子:7.014)

    3.      Huang, Z.P., Kataoka, M., Chen, J., Wu, G., Ding, J., Nie, M., Lin, Z., Liu, J., Hu, X., Ma, L., Zhou, B., Wakimoto, H., Zeng, C., Kyselovic, J., Deng, Z.L., Seidman, C.E., Seidman, J.G., Pu, W.T. and Wang, D.Z. Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis. The Journal of clinical investigation. 2015, 125:4122-4134. (2018SCI影响因子:12.282)

    4.      Huang, Z.P., Chen, J., Seok, H.Y., Zhang, Z., Kataoka, M., Hu, X. and Wang, D.Z. MicroRNA-22 Regulates Cardiac Hypertrophy and Remodeling in Response to Stress. Circulation Research, 2013, 112: 1234-1243. (2018SCI影响因子:15.862)

    5.      Huang, Z.P., Seok, H.Y., Zhou, B., Chen, J., Chen, J., Tao, Y., Pu, W.T., and Wang, D.Z. CIP, a cardiac ISL1-interacting protein, represses cardiomyocyte hypertrophy. Circulation Research, 2012, 110: 818-830. (2018SCI影响因子:15.862)

    6.      Huang, Z.P., Chen, J.F., Regan, J.N., Maguire, C.T., Tang, R.H., Dong, X.R., Majesky, M.W., and Wang, D.Z. Loss of MicroRNAs in Neural Crest Leads to Cardiovascular Syndromes Resembling Human Congenital Heart Defects. Arteriosclerosis, thrombosis, and vascular biology, 2010, 30: 2575-2586. (封面论文) (2018SCI影响因子6.618)

    7.      Huang, Z.P.* and Wang, D.Z*. miR-22 in cardiac remodeling and disease. Trends in Cardiovascular Medicine. 2014, 24:267-272.  (2018SCI影响因子:4.462)

    8.      Huang, Z.P. and Wang, D.Z. Response to "Human Genome Organization-Symbolized Muscle-Enriched A-Type Lamin-Interacting Protein to Clear Up Confusion". Circulation Research, 2012, 111: E253-E254. (2018SCI影响因子:15.862)

    9.      Huang, Z.P., Espinoza-Lewis, R. and Wang, D.Z. Determination of MiRNA Targets in Skeletal Muscle Cells. Methods in Molecular Biology, 2012, 798: 475-490.

    10.  Huang, Z.P., Neppl, R.L. and Wang, D.Z. Application of microRNA in cardiac and skeletal muscle disease gene therapy. Methods in Molecular Biology, 2011, 709: 197-210.

    11.  Huang, Z.P., Neppl, R.L. and Wang, D.Z. MicroRNAs in cardiac remodeling and disease. Journal of Cardiovascular Translational Research, 2010, 3: 212-218. (2018SCI影响因子:2.756)

    12.  Huang, Z.P., Chen, C.J., Zhou, H., Li, B.B. and Qu, L.H. A combined computational and experimental analysis of two families of snoRNA genes from Caenorhabditis elegans, revealing the expression and evolution pattern of snoRNAs in nematodes. Genomics, 2007, 89: 490-501. (2018SCI影响因子:3.160)

    13.   Huang, Z.P., Zhou, H. and Qu, L.H. Maintaining a conserved methylation in plant and insect U2 snRNA through compensatory mutation by nucleotide insertion. IUBMB Life, 2005, 57: 693-699. (2018SCI影响因子:3.051)

    14.  Huang, Z.P., Zhou, H., He, H.L., Chen, C.L., Liang, D. and Qu, L.H. Genome-wide analyses of two families of snoRNA genes from Drosophila melanogaster, demonstrating the extensive utilization of introns for coding of snoRNAs. RNA, 2005, 11: 1303-1316. (2018SCI影响因子:3.949)

    Huang, Z.P., Zhou, H., Liang, D., and Qu, L.H. Different expression strategy: multiple intronic gene clusters of box H/ACA snoRNA in Drosophila melanogaster. Journal of Molecular Biology, 2004, 341 669-683. (2018SCI影响因子:5.067)