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    邵兰

    医疗/科研特长:

    长期从事慢性免疫病研究,在艾默里大学和斯坦福大学工作期间,发现了自身免疫病病人免疫细胞中ATM蛋白主导的DNA 损伤修复通路的缺陷可导致免疫细胞修复功能的缺失,免疫系统长期处于增殖压力下,最终导致免疫衰老和自身免疫识别的异常。此发现从一定程度改变了传统上人们对自身免疫病的认识。在美国耶鲁大学医学院工作期间,深入研究了表观遗传修饰酶--SUMO特异性蛋白酶(SENP1),并首次证明了NEMOSUMO化特异性增强胰岛脂肪细胞炎性细胞介素的分泌,进而导致自发性糖尿病,从而首次揭示SENP1作为敏感基因在糖尿病发病中的作用。相关结果分别发表在J .Exp Med.Nature CommunicationNature Review RheumatologyPNASEMBO MM,  Journal of Autoimmunity. Arthritis & rheumatism., Frontiers in Immunology等国际著名的医学杂志。并被美国临床免疫学会(FOCIS),美国免疫学会(AAI),美国类风湿学会(ACR)邀请作大会报告。此外还拥有斯坦福大学技术许可证明1项,美国专利1项及国内专利2项。

     

    研究方向:临床免疫学及肿瘤免疫

     

    主要教育和工作经历:

    沈阳药科大学                药学         学士

    沈阳药科大学                药理         硕士

    中科院研究生院            细胞生物学     博士

    2002.8-2007.3      中科院动物所       助理研究员

    2006.4-2009.12     艾默里大学(Emory   博士后

    2009.12-2011.6     斯坦福大学(Stanford博士后

    2011.4-2012.4      斯坦福大学(Stanford研究助理

    2012.8-2016.3      耶鲁大学(Yale       副研究员

    2016.4-至今        中山大学                   研究员


    社会兼职:

     

    论著:

    1         Qiao Su#, jun Jing#, Wuguo Li, Jianda Ma, Xueling zhang, Zongren Wang, Zhongyang Zhou, Lie Dai*, Lan Shao*, Impaired Tip60-mediated Foxp3 acetylation attenuates regulatory T cell development in rheumatoid arthritis, Journal of Autoimmunity, 2019, 100, 27-29. (IF: 7.54)

    2         JianDa Ma, Jun Jing, JunWei Wang, Ying-Qian Mo, QianHua Li, JianZi Lin, LeFeng  Shao L *#, Pierre Miossec, Lie Dai# . Activation of the PGC1β/NFATc1 Pathway in Circulating Osteoclast Precursors Associated with Bone Destruction in Rheumatoid Arthritis. Arthritis & rheumatism. 2019 Aug;71(8):1252-1264.(IF: 9.02)

    3         Shao L * DNA damage response signals transduce stress from rheumatoid arthritis risk factors into T cell dysfunction. Frontiers in immunology. Frontiers in immunology. 2018, December, Vol: 9:3055

    4         张雪玲,李武国,周仲洋,郑漫妮,邵兰*. T 细胞代谢异常对类风湿关节炎发生发展影响。中华风湿病学杂志. 2018, 22(11), 114-116.1

    5         Shao L, Feng BY, Zhou HJ, Ji WD, Wang Min* The role of adipose derived inflammatory cytokines in type 1 diabetes (2016). Adipocyte 17 Mar 2016:1-5. (IF: 3.55)

    6         邵兰,冯博雅, 张钰莹, 周焕娇,纪卫东,王敏(2016).脂肪组织与型糖尿病。千人生物2016, 3(1), 1-6

    7         Shao L, Zhou HJ, Zhang HF, Wang Min (2015).  SENP1-mediated NEMO deSUMOyation in the adipocyte limits inflammatory responses and type 1 diabetes progression. Nat. Commun. 2015, Nov 24. (IF: 12.12)

    8         Shao L, Goronzy JJ, Weyand CM (2010). Inhibition of the DNA repair enzyme DNA-PKcs restores T cell survival in rheumatoid arthritis. EMBO Molecular Medicine. 2010 2 (10):415-27. (IF: 11.549)

    9         Goronzy JJ, Shao L, Weyand CM (2010). New insights into Rheumatoid Arthritis. Rheumatic Disease Clinics of North America. 2010 36 (2). 297-310. (IF: 3.34)

    10     Shao L, Fujii H, Goronzy JJ, Weyand CM (2009). Deficiency of the DNA repair enzyme ATM in Rheumatoid Arthritis. J.Exp.Med. 2009 Jun; 8; 206(6): 1435-49. (IF: 11.9)

    11    Weyand CM, Fujii H, Shao L, Goronzy JJ (2009).Rejuvenating the immune system in rheumatoid arthritis. Nat Rev Rheumatol. 2009 5, 583-588. (IF: 18.68)

    12     Fujii H, Shao L, Goronzy JJ, Weyand CM (2009). Telomerase insufficiency in rheumatoid arthritis. Proc Natl Acad Sci U S A. 2009 Mar 17; 106(11): 4360-5. (IF: 9.81)

    13     Shao L, Li QH, Wang J, Tan Z (2005). Fragmentation and rapid shortening of telomere in HeLa cells in the early phase of hydroxyl radical-induced apoptosis. Cancer Biol Ther. 2005; 4(3):336-41.(IF: 3.63)

    14     Shao L, Li QH, Tan Z (2004). L-carnosine reduces telomere damage and shortening rate in cultured normal fibroblasts. Biochem Biophys Res Commun. 2004, 324(2): 931-936.(IF: 2.4)

    15    Yang F, Yang JP, Li QH, Shao L (2003). Strand breaks in telomeres in Hela cells. Acta Zoology Sinica. 2003, 49 (6): 873-877.

    16    Shao L, Huang Q, Li QH (2003). Regulation effect of insulin on metabolic dysfunction of diabetic rats. Chinese Journal of Zoology. 2003, 38(2): 23-27.

    17    Shao L, Li QH, Huang Q (2002). Effect of insulin on oxidative damage in liver of diabetic rats. Chinese Journal of Zoology. 2002, 37(5): 28-31.

    18    Jiao XM, Li QH, Xu M, Li LJ, Shao L (2002). Fusion of Ehrlich′s ascites cell plasma membrane with liposomes driven by transmembrane pronton efflux: effect of calcium ions and liposome phospholipid composition. Acta Zoologica Sinica. 2002, 48 (5): 660-666.

    19    Huang Q, Shao L, Jiang H (2001). Effect of insulin on oxygen free radicals and oxidative phosphorylation in liver mitochondrial of diabetic rats. Acta. Pharmacol. Sina. 2001, 22(5): 455-458. (IF:2.496)

    20    Shao L, Yu QH, Huang Q (2001). The effect of Houttuyninum on cellular immunological function in splenectomy animals. Chinese Pharmacological Bullitin.2001, 17(1): 51-54.

    21    Shao L,Yu QH (2000). The effect of Houttuyninum on immunological function in mice treated with cyclophosphamide. Journal of Shenyang Pharmacoeuticel University. 2000, 17(2): 133-135.

    22    Shao L,Yu QH (1999). The effect of Houttuyninum on immunological function in splenectomy animals. Journal of Shenyang Pharmacoeuticel University. 1999, 16(3): 209-211.

    23    Shao L,Yu QH (1998). The Improving Effect of Decoction of Coptis and Its Extract on Intelligence.Journal of Shenyang Pharmacoeuticel University. 1998, 15 (1): 35~37.

    24    Ye FG, Yu QH, Shao L (1998).  Antioxidant Activity of Calculus Borisfor Lipid. China Journal of Traditional Chinese Medicine and Pharmacy. 1998, 13 (2): 69.

    25    Yu QH, Zhang YF, Shao L (1997). The role of Immune regulation of Chinese Medicine. Medical Journal of Liaoning. 1997, 11(6): 299-301.

     

    专利

    1      Weyand CM, Goronzy JJ, Shao L. Improving Immune System Function in conditions characterized by elevated double strand breaks (U.S. Patent Application Serial No. 13/205,001, issued data 12/6/2016).

    2      Zhao Y, Xie W, Shao L. A tetramer combined with SARS Antigen Peptide, its preparation and use (No. 200310113727).

     

    其他主要工作成绩:

    中山大学附属第一医院  2015高影响因子奖

    美国免疫学年会大会奖(AAI 2010

    美国临床免疫学年会大会奖 (FOCIS 2009)