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    杨蜀岚

    医疗/科研特长

    主要以斑马鱼为模式动物研究人类重要疾病相关基因的功能。以第一/通讯(共同第一/通讯)作者发表SCI论文10多篇,其中2篇论文获得Faculty of 1000推荐。

     

    研究方向:人类疾病相关易感基因的致病机制研究

     

    主要教育和工作经历:

    200012月获博士学位。2001年到2011年期间,先后在新加坡分子和细胞生物学研究院(IMCB)从事博士后研究和担任研究员、资深研究员工作,主要以模式生物拟南芥、斑马鱼为研究对象,研究机体器官发育的分子机理。201112月,作为中山大学“百人计划”引进人才到本院工作,建立了斑马鱼疾病模式动物公共平台,开展人类疾病相关易感基因的致病机制研究。



     

    社会兼职:

    广东省精准医学应用学会疾病模型分会第一届委员会副主任委员。

    中国实验动物学会水生实验动物专业委员会委员。

     

    论著:

    Wang J#, Guo X, Wang D, Yang S*, Expression patterns of pcbp gene family members during zebrafish embryogenesis. Gene Expr Patterns. 2020 Jan 31; 35:119097. doi: 10.1016/j.gep.2020.119097. [Epub ahead of print]

    Zhang M#, Wei Y, Liu Y, Guan W, Zhang X, Kong J, Li H, Yang S*, Wang H*, Metastatic Phosphatase PRL-3 induces Ovarian Cancer Stem Cell Subpopulation through Phosphatase-independent Deacetylation Modulations. iScience 2020 Jan 24;23(1):100766. doi: 10.1016/j.isci.2019.100766.

    Shi H#, Li H#, Yuan R#, Guan W, Zhang X, Zhang S, Zhang W, Tong F, Li L, Song Z, Wang C, Yang S*., Wang H*.. PCBP1 depletion promotes tumorigenesis through attenuation of p27 Kip1 mRNA stability and translation. Journal of  Experimental & Clinical Cancer Research, 2018, 37187. ePubdoi: 10.1186/s13046-018-0840-1.

    Xu L#, Zhang M, Li H, Guan W, Liu B, Liu F, Wang H, Li Juan, Yang S, Tong X*Wang H*. SH3BGRL as a novel prognostic biomarker is down-regulated in acute myeloid leukemia. Leuk Lymphoma. 2018, 59(4):918-930.

    Gao W#, Chen C#, Zhou T#, Yang S, Gao B, Zhou H, Lian C, Wu Z, Qiu X, Yang X, Alattar E, Liu W, Su D, Sun S, Chen Y, Cheung KMC, Song Y, Luk KKD, Chan D, Sham PC, Xing C, Khor CC, Liu G, Yang J, Deng Y, Hao D, Huang D, Li QZ, Xu C*, Su P*. Rare coding variants in MAPK7 predispose to adolescent idiopathic scoliosis.  Human Mutation. 2017, 38(11):1500-1510

    Li L#, Shi H#, Zhang M, Guo X, Tong F, Zhang W, Zhou J, Wang H*, Yang S*. Upregulation of metastasis-associated PRL-3 initiates chordoma in zebrafish. International Journal of Oncology, 2016, 48(4):1541-1552.

    Tong F#, Zhang M, Guo X, Shi H, Guan W, Wang H* and  Yang S*. Expression patterns of SH3BGR family members in zebrafish development. Development Genes and Evolution 2016, 226(4): 287-295.

    Zhang W#, Shi H#, Zhang M, Liu B, Mao S, Li L, Tong F, Liu G, Yang S*, Wang H*. Poly C binding protein 1 represses autophagy through downregulation of LC3B to promote tumor cell apoptosis in starvation. International Journal of Biochemistry and Cell Biology. 2016, 73: 127-136.

    Qu S#,  Liu B, Guo X, Shi H, Zhou M, Li L,  Yang S,  Tong X*,  Wang H*. Independent oncogenic and therapeutic significance of phosphatase PRL-3 in FLT3-ITD–negative acute myeloid leukemia Cancer. 2014, 120(14): 2130-2141.

    Yang S #, Aw SS, Chang Q, Korzh S, Korzh V*, and Peng J*. Depletion of Bhmt elevates sonic hedgehog transcript levels to promote pancreatic islet development in zebrafish, Endocrinology, 2011: 152(12):4706-4717.

    Korzh S, Winata CL, Zheng W, Yang S, Yin A, Ingham P, Gong Z*.  The interaction of epithelial Ihha and mesenchymal Fgf10 in zebrafish esophageal and swimbladder development. Developmental Biology, 2011,359262–276.

    Ma H#, Zhang S, Ji L, Zhu H, Yang S, Fang X*, Yang R*. Mapping and in silico isolation of the EUI1 gene controlling upper internode elongation in rice. Plant Molecular Biology, 2006, 60: 87-94

    Yang S #, Puah CS, Xie L, Jiang L, Zhang X, Chen L, Ye D*. Over-expression of TPD1 alters the cell fates in the arabidopsis carpel and tapetum via genetic Interaction with EMS1/EXS. Plant Physiology, 2005, 139: 186-191.

    Jiang L#, Yang S#, Xie L, Puah CS, Yang W, Sundaresan V, Ye D*. VANGUARD1  encodes a pectin methylesterase that enhances pollen tube growth in the Arabidopsis style and transmitting tract. Plant Cell, 2005, 17: 584-596. (Faculty of 1000 推荐).

    Yang S #, Xie L, Mao H, Puah CS, Yang W, Jiang L, Ye D*. 2003. Tapetum determinant 1 gene is required for cell specialization in the Arabidopsis anther. Plant Cell, 15: 2792-2804. (Faculty of 1000推荐).