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    王敏

    王敏
    • 科  室:
    • 职  称:教授
    • 导师资格:博士生导师
    • 最高学历:博士研究生
    出诊时间
    周一 周二 周三 周四 周五 周六 周日
    上午
    下午
    晚上
    (注:出诊信息仅供参考,有可能随时更新,以门诊公布为准。)

    医疗/科研特长

    长期从事炎症及血管生物的信号传导通路的基础研究,在炎症、新生血管的信号传导途径及抗炎、抗新生血管的研究中取得许多重要的发现。在Nature BiotechnologyNature Medicine, JACC, Circulation, Circulation Research, JCIJEM, Science Signaling, Cell, PNAS等国际著名期刊发表论文100余篇。近五年发表论文44篇,其中通讯作者30篇,影响因子高于1016篇;多次作为特邀演讲嘉宾参与并主持国际学术会议。

    研究方向:炎症和血管生物学研究

    主要教育和工作经历:主要教育和工作经历:19846月毕业于武汉大学,获微生物学学士学位;19896月毕业于中科院上海细胞生物学研究所,获细胞生物学硕士学位;19936月毕业于英国威尔士大学,获分子生物学和遗传学博士学位;19937月至19977月在耶鲁大学从事博士后研究,1999年至2014年先后在罗彻斯特大学和耶鲁大学担任助理教授、副教授、终身教授。20144月作为中山大学“百人计划”领军人才引进至中山大学附属第一医院工作,任转化医学研究中心主任。


    社会兼职:

    美国耶鲁大学医学院病理系研究生招生委员会主任,耶鲁大学病理学研讨会召集人,美国国立卫生研究院(NIH)研究部(AICS)常务委员,美国NIH基金评审专家,美国NIH “肿瘤微环境”和美国NIH “血脑屏障与疾病”特别评审成员,美国心脏协会(AHA)国家基金评审专家;Arteriosclerosis, Thrombosis,and Vascular Biology , Frontiers in Physiology等杂志编委,ScienceNature Medicine, J. Clin. Invest.OncogenePNAS Cancer Research等杂志审稿人。

     

    论著:

    1.     Zhu X, Ding S, QiuC, Shi Y, Song L, Wang Y, Wang Y, Li J, Wang Y, Sun Y, Qin L, Chen J, Simons M,Min W*, Yu L, SUMOylationNegatively Regulates Angiogenesis by Targeting Endothelial NOTCH Signaling,Circ Res. 2017.

    2.     Qiu C, Wang Y, Zhao, H, Qin L, Shi Y, Zhu, X, Song L, Zhou, X, Chen J,Zhou H, Zhang, H, Tellides G, Min W, Yu L (2017) The critical role ofSENP1-mediated GATA2 deSUMOylation in graft arteriosclerosis by promotingendothelial activation.NatureCommunications 8:15426.PMCID:PMC5461500.

    3.     Yin, M, Zhou HJ, Zhang, JQ, Lin CX, Li,HM, Li, X, Li, YH, Zhang HF, Breckenridge D, Ji, W, Min, W* (2016) ASK1-dependent endothelial cell activation is critical inovarian cancer growth and metastasis, JCI Insight 2017.

    4.     Qiu C, Wang Y, ZhaoH, Qin L, Shi Y, Zhu X, Song L, Zhou X, Chen J, Zhou H, Zhang H, Tellides G, Min W*, Yu L. The critical roleof SENP1-mediated GATA2 deSUMOylation in promoting endothelial activation ingraft arteriosclerosis. Nat Commun. 2017.

    5.     Zhou HJ, Qin L, Zhang H, Tang, W, Ji, W,He Y, Liang, X, Wang Z, Yuan Q, Vortmeyer A, Toomre D, Fuh G, Yan M, Kluger MS,Wu D, Min W* (2016). Endothelialexocytosis of angiopoietin-2 resulting from CCM3-deficiency contributes tocerebral cavernous malformation. Nature Medicine 22(9):1033-42. PMCID: PMC5014607.News and Views at: http://www.nature.com/nm/journal/v22/n9/full/nm.4178.html.Yalenews

    6.     Yin, M, Li, X, Tan S, Zhou HJ, Zhang HF,Ji, W, Bellone, S, Santin, A, Ge, L, Min, W* (2016) Tumor-Associated Macrophages Drive Spheroid Formation During EarlyTranscoelomic Metastasis of Ovarian Cancer. J Clin Invest. 126(11):4157-73. PMCID:PMC5096908. http://news.yale.edu/2016/10/18/insight-ovarian-cancer.See video at http://www.jci.org/posts/499.(highlighted by cover image).

    7.     Shao, L, Zhou HJ, Zhang H, Qin L, Hwa,J, Yun Z, Ji, W, Min W* (2015). SENP1-mediated NEMO deSUMOylation in theadipocyte limits inflammatory responses and type 1 diabetes progression.Nature Communications 6:8917. doi: 10.1038/ncomms9917.PMCID: PMC4662081.

    8.     Ji W, Li Y, He Y,Yin M, Zhou HJ, Boggon TJ, Zhang H, MinW*. AIP1 Expression in Tumor Niche Suppresses Tumor Progression andMetastasis. Cancer Research, 2015, 75(17):3492-504.

    9.     Huang Q, Zhou HJ,Zhang H, Huang Y, Hinojosa-Kirschenbaum F, Fan P, Yao L, Belardinelli L,Tellides G, Giordano FJ, Budas GR, MinW*.Thioredoxin-2 inhibits mitochondrial reactive oxygen speciesgeneration and apoptosis stress kinase-1 activity to maintain cardiac function.Circulation, 2015, 131(12):1082-97.

    10.  Qin, L., Huang, Q., Zhang, H., Liu, R., Tellides, G., Min W*, Yu, L*. (2014). SOCS1prevents graft arteriosclerosis by preventing endothelial cell function. J AmerColl of Cardiol. 63(1):21-9 (*Min is contacting senior author). Also seecommentary in this issue by Weger, RA Immune regulators regulated to preventtransplant reactions. This work was the winner for JACC Parmley Award in 2014.

    11.  Zhang, Y., Tang, W., Zhang, H., Niu, X., Xu, Y., Zhang,J., Gao, K., Boggon, TJ., Toomre, D., MinW*, Wu, D.* Important roles of the CCM3 and STK24 Complex in regulationof Ca2+-stimulated exocytosis. Dev Cell. 27(2):215-26. (*Min isco-corresponding author). PMCID: PMC3834565.

    12.  Pasula S,  Cai  X, Dong  Y,  Messa, M,  McManus  J, Chang  B,  Liu X,  Zhu  H, Mansat  R,  Yoon S,  Hahn  S, Keeling J, Saunders D, Ko G, Newton G,Luscinskas F, Sun X, Towner R, Lupu, F, Xia L, Cremona O, De Camilli P, Min W* ,  Chen H. * . Endothelial  epsin  deficiency decreases   tumor  growth by  enhancing  VEGF signaling.  J. Clin  Invest ,  122 (12):4424 - 4438,2012. *Also seecommentary in this issue, J. Clin Invest, 122(12):4341-4343, 2012. Andhighlights in Nature Reviews Cancer13: issue of January 2013.

    13.  Yu L , Qin L , Zhang H , He Y , Chen H , Pober JS ,Tellides G , and Min W* .AIP1 prevents arteriosclerosis by inhibiting IFN-γ-dependent smooth muscle cellproliferation and intimal expansion . Cir Res . 109(4):418-27 . (2011) .

    14.  Xie D, Gore C, Liu J, Pong RC, Mason R, Hao G, Long M,Kabbani W, Yu L, Zhang H, Chen H, Sun X, Boothman DA, Min W*, Hsieh JT*. Role of DAB2IP in modulatingepithelial-to-mesenchymal transition and prostate cancer metastasis. ProcNatl  Acad Sci U S A.107(6):2485-90.2010.

    15.  Yu L , Ji W , Zhang H , Renda MJ , He Y , Lin S , Cheng E, Chen H , Krause DS , and Min W*. SENP1-mediated GATA1 desumoylation is critical for definitive erythropoiesis. J Exp Med . 207(6):1183-95 . (2010) .

    16.  He Y , Zhang H , Yu L , Gunel M , Boggon T , Chen H* ,and Min W* .  Stabilization of VEGFR2 signaling by cerebralcavernous malformation 3 is critical  forvascular development . Science Signaling . 3(116):ra26 . (2010) .

    专著:

     

    其他主要工作成绩(比如获奖情况):

    5年共获美国NIH资助5项;获中国国家自然科学基金海外青年合作基金一项。

    获奖情况:
    1998    
    基因医学杰出个人奖, ValentisInc.

    2003     5ATVB会议Irvine H. Page青年研究者研究奖

    2004     AHA国家杰出研究者奖

    2014     JACC Parmley Award (年度最佳文章奖)

    2014     康州干细胞杰出研究者奖