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    邵兰

    邵兰
    • 科  室:
    • 职  称:研究员
    • 导师资格:博士生导师
    • 最高学历:博士
    出诊时间
    周一 周二 周三 周四 周五 周六 周日
    上午
    下午
    晚上
    (注:出诊信息仅供参考,有可能随时更新,以门诊公布为准。)

    医疗/科研特长

    长期从事慢性免疫病研究,在艾默里大学和斯坦福大学工作期间,发现了自身免疫病病人免疫细胞中ATM蛋白主导的DNA 损伤修复通路的缺陷可导致免疫细胞修复功能的缺失,免疫系统长期处于增殖压力下,最终导致免疫衰老和自身免疫识别的异常。此发现从一定程度改变了传统上人们对自身免疫病的认识。在美国耶鲁大学医学院工作期间,深入研究了表观遗传修饰酶--SUMO特异性蛋白酶(SENP1),并首次证明了NEMOSUMO化特异性增强胰岛脂肪细胞炎性细胞介素的分泌,进而导致自发性糖尿病,从而首次揭示SENP1作为敏感基因在糖尿病发病中的作用。相关结果分别发表在J .Exp Med.Nature CommunicationNature Review RheumatologyPNASEMBO MM 等国际著名的医学杂志。并被美国临床免疫学会(FOCIS),美国免疫学会(AAI),美国类风湿学会(ACR)邀请作大会报告。此外还拥有斯坦福大学技术许可证明1项,美国专利1项及国内专利2项。


    研究方向:糖尿病与自身免疫病


    主要教育和工作经历

    沈阳药科大学                药学         学士

    沈阳药科大学                药理         硕士

    中科院研究生院            细胞生物学     博士

    2002.8-2007.3      中科院动物所       助理研究员

    2006.4-2009.12     艾默里大学(Emory   博士后

    2009.12-2011.6     斯坦福大学(Stanford博士后

    2011.4-2012.4      斯坦福大学(Stanford研究助理

    2012.8-2016.3      耶鲁大学(Yale       副研究员

    2016.4-至今        中山大学                  研究员


    社会兼职:

     

    论著:

    1        ShaoL, Feng BY, Zhou HJ, Ji WD, Wang Min* The role of adipose derivedinflammatory cytokines in type 1 diabetes (2016). Adipocyte 17 Mar 2016:1-5.

    2        邵兰,冯博雅, 张钰莹, 周焕娇,纪卫东,王敏(2016).脂肪组织与型糖尿病。千人生物2016, 3(1), 1-6

    3        ShaoL, Zhou HJ, Zhang HF, Wang Min(2015).  SENP1-mediated NEMO deSUMOyationin the adipocyte limits inflammatory responses and type 1 diabetes progression.Nat. Commun. 2015, Nov 24. (IF: 11.47)

    4        ShaoL, Goronzy JJ, Weyand CM (2010).Inhibition of the DNA repair enzyme DNA-PKcs restores T cell survival inrheumatoid arthritis. EMBO Molecular Medicine. 20102 (10):415-27. (IF: 8.89)

    5        Goronzy JJ, Shao L, Weyand CM (2010). New insightsinto Rheumatoid Arthritis. Rheumatic Disease Clinics of North America. 2010 36(2). 297-310.(IF: 3.02)

    6        ShaoL, Fujii H, Goronzy JJ, Weyand CM (2009).Deficiency of the DNA repair enzyme ATM in Rheumatoid Arthritis. J.Exp.Med.2009 Jun; 8; 206(6): 1435-49.(IF: 13.9)

    7       Weyand CM,Fujii H, Shao L, Goronzy JJ (2009).Rejuvenating the immune system inrheumatoid arthritis. Nat Rev Rheumatol. 2009 5, 583-588.(IF: 10.51)

    8        Fujii H, Shao L, Goronzy JJ, Weyand CM (2009). Telomerase insufficiency inrheumatoid arthritis. Proc Natl Acad Sci U S A.2009 Mar 17; 106(11): 4360-5. (IF: 9.81)

    9        ShaoL, Li QH, Wang J, Tan Z (2005).Fragmentation and rapid shortening of telomere in HeLa cells in the early phaseof hydroxyl radical-induced apoptosis. Cancer Biol Ther. 2005; 4(3):336-41.(IF:3.63)

    10    ShaoL, Li QH, Tan Z (2004). L-carnosine reduces telomere damage and shortening ratein cultured normal fibroblasts. Biochem BiophysRes Commun. 2004, 324(2): 931-936.(IF: 2.4)

    11   Yang F, YangJP, Li QH, Shao L (2003). Strandbreaks in telomeres in Hela cells. Acta Zoology Sinica. 2003, 49 (6): 873-877.

    12   ShaoL, Huang Q, Li QH (2003). Regulationeffect of insulin on metabolic dysfunction of diabetic rats. Chinese Journal ofZoology. 2003, 38(2): 23-27.

    13   ShaoL, Li QH, Huang Q (2002). Effect ofinsulin on oxidative damage in liver of diabetic rats. Chinese Journal ofZoology. 2002, 37(5): 28-31.

    14   Jiao XM, LiQH, Xu M, Li LJ, Shao L (2002).Fusion of Ehrlich′s ascites cell plasma membrane with liposomes driven bytransmembrane pronton efflux: effect of calcium ions and liposome phospholipidcomposition. Acta Zoologica Sinica. 2002, 48 (5): 660-666.

    15   Huang Q, Shao L, Jiang H (2001). Effect ofinsulin on oxygen free radicals and oxidative phosphorylation in livermitochondrial of diabetic rats. Acta. Pharmacol. Sina. 2001, 22(5): 455-458.(IF:2.496)

    16   ShaoL, Yu QH, Huang Q (2001). The effect ofHouttuyninum on cellular immunological function in splenectomy animals. ChinesePharmacological Bullitin.2001, 17(1): 51-54.

    17   ShaoL,Yu QH (2000). The effect of Houttuyninum on immunological function in micetreated with cyclophosphamide. Journal of Shenyang Pharmacoeuticel University.2000, 17(2): 133-135.

    18   ShaoL,Yu QH (1999). The effect of Houttuyninum on immunological function insplenectomy animals. Journal of Shenyang Pharmacoeuticel University. 1999,16(3): 209-211.

    19   ShaoL,Yu QH (1998). TheImproving Effect of Decoction of Coptis and Its Extract on Intelligence.Journalof Shenyang Pharmacoeuticel University. 1998, 15 (1): 35~37.

    20   Ye FG, Yu QH, Shao L (1998).  Antioxidant Activity of Calculus Borisfor Lipid. China Journal of TraditionalChinese Medicine and Pharmacy. 1998, 13 (2): 69.

    21   Yu QH, ZhangYF, Shao L (1997). The role ofImmune regulation of Chinese Medicine. Medical Journal of Liaoning. 1997,11(6): 299-301.

     

    专著:

    Methodsfor Reversing Protein Modification: Ubiquitin and SUMO-specific Proteases”.(2017Taylor & Francis Publications).

    专著章节

    SENP1-mediatedSignaling in Adipocytes and Type-1 Diabetes Progression.

    Lan Shao, Tingting Liu, HaixuanChen, and Wang Min 

     

    其他主要工作成绩(比如获奖情况)

    中山大学附属第一医院 2015高影响因子奖

    美国免疫学年会大会奖(AAI 2010

    美国临床免疫学年会大会奖 (FOCIS 2009)