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邵兰

邵兰
  • 科  室:
  • 职  称:研究员
  • 导师资格:博士生导师
  • 最高学历:博士
出诊时间
周一 周二 周三 周四 周五 周六 周日
上午
下午
晚上
(注:出诊信息仅供参考,有可能随时更新,以门诊公布为准。)
医疗/科研特长:
长期从事慢性免疫病研究,在艾默里大学和斯坦福大学工作期间,发现了自身免疫病病人免疫细胞中ATM蛋白主导的DNA 损伤修复通路的缺陷可导致免疫细胞修复功能的缺失,免疫系统长期处于增殖压力下,最终导致免疫衰老和自身免疫识别的异常。此发现从一定程度改变了传统上人们对自身免疫病的认识。在美国耶鲁大学医学院工作期间,深入研究了表观遗传修饰酶--SUMO特异性蛋白酶(SENP1), 并首次证明了NEMO的SUMO化特异性增强胰岛脂肪细胞炎性细胞介素的分泌,进而导致自发性糖尿病, 从而首次揭示SENP1作为敏感基因在糖尿病发病中的作用。相关结果分别发表在J .Exp Med.,Nature Communication,Nature Review Rheumatology,PNAS,EMBO 等国际著名的医学杂志。并被美国临床免疫学会(FOCIS),美国免疫学会(AAI),美国类风湿学会(ACR)邀请作大会报告。此外还拥有斯坦福大学技术许可证明1项,美国专利1项及国内专利2项。

研究方向:心血管代谢异常与疾病,自身免疫病,糖尿病, 干细胞分化

主要教育和工作经历:
沈阳药科大学      药学                 学士
沈阳药科大学      药理                 硕士
中科院研究生院  细胞生物学     博士
2002.8-2007.3      中科院动物所       助理研究员
2006.4-2009.12    艾默里大学(Emory)   博士后
2009.12-2011.6    斯坦福大学(Stanford) 博士后
2011.4-2012.4      斯坦福大学(Stanford) 研究助理
2012.8-2016.3      耶鲁大学(Yale)       副研究员
2016.4-至今         中山大学                   研究员


论著:
1 Shao L, Feng BY, Zhou HJ, Ji WD, Wang Min* The role of adipose derived inflammatory cytokines in type 1 diabetes (2016). Adipocyte 17 Mar 2016:1-5.
2 邵兰,冯博雅, 张钰莹, 周焕娇,纪卫东,王敏(2016).脂肪组织与Ⅰ型糖尿病。千人生物 2016, 3(1), 1-6。
3 Shao L, Zhou HJ, Zhang HF, Wang Min (2015).  SENP1-mediated NEMO deSUMOyation in the adipocyte limits inflammatory responses and type 1 diabetes progression. Nat. Commun. 2015, Nov 24. (IF: 11.47)
4 Shao L, Goronzy JJ, Weyand CM (2010). Inhibition of the DNA repair enzyme DNA-PKcs restores T cell survival in rheumatoid arthritis. EMBO Molecular Medicine. 2010 2 (10):415-27. (IF: 8.89)
5 Goronzy JJ, Shao L, Weyand CM (2010). New insights into Rheumatoid Arthritis. Rheumatic Disease Clinics of North America. 2010 36 (2). 297-310.(IF: 3.02)
6 Shao L, Fujii H, Goronzy JJ, Weyand CM (2009). Deficiency of the DNA repair enzyme ATM in Rheumatoid Arthritis. J.Exp.Med. 2009 Jun; 8; 206(6): 1435-49.(IF: 13.9)
7 Weyand CM, Fujii H, Shao L, Goronzy JJ (2009). Rejuvenating the immune system in rheumatoid arthritis. Nat Rev Rheumatol. 2009 5, 583-588.(IF: 10.51)
8 Fujii H, Shao L, Goronzy JJ, Weyand CM (2009). Telomerase insufficiency in rheumatoid arthritis. Proc Natl Acad Sci U S A. 2009 Mar 17; 106(11): 4360-5. (IF: 9.81)
9 Shao L, Li QH, Wang J, Tan Z (2005). Fragmentation and rapid shortening of telomere in HeLa cells in the early phase of hydroxyl radical-induced apoptosis. Cancer Biol Ther. 2005; 4(3):336-41.(IF: 3.63)
10 Shao L, Li QH, Tan Z (2004). L-carnosine reduces telomere damage and shortening rate in cultured normal fibroblasts. Biochem Biophys Res Commun. 2004, 324(2): 931-936.(IF: 2.4)
11 Yang F, Yang JP, Li QH, Shao L (2003). Strand breaks in telomeres in Hela cells. Acta Zoology Sinica. 2003, 49 (6): 873-877.
12 Shao L, Huang Q, Li QH (2003). Regulation effect of insulin on metabolic dysfunction of diabetic rats. Chinese Journal of Zoology. 2003, 38(2): 23-27.
13 Shao L, Li QH, Huang Q (2002). Effect of insulin on oxidative damage in liver of diabetic rats. Chinese Journal of Zoology. 2002, 37(5): 28-31.
14 Jiao XM, Li QH, Xu M, Li LJ, Shao L (2002). Fusion of Ehrlich′s ascites cell plasma membrane with liposomes driven by transmembrane pronton efflux: effect of calcium ions and liposome phospholipid composition. Acta Zoologica Sinica. 2002, 48 (5): 660-666.
15 Huang Q, Shao L, Jiang H (2001). Effect of insulin on oxygen free radicals and oxidative phosphorylation in liver mitochondrial of diabetic rats. Acta. Pharmacol. Sina. 2001, 22(5): 455-458. (IF:2.496)
16 Shao L, Yu QH, Huang Q (2001). The effect of Houttuyninum on cellular immunological function in splenectomy animals. Chinese Pharmacological Bullitin.2001, 17(1): 51-54.
17 Shao L, Yu QH (2000). The effect of Houttuyninum on immunological function in mice treated with cyclophosphamide. Journal of Shenyang Pharmacoeuticel University. 2000, 17(2): 133-135.
18 Shao L, Yu QH (1999). The effect of Houttuyninum on immunological function in splenectomy animals. Journal of Shenyang Pharmacoeuticel University. 1999, 16(3): 209-211.
19 Shao L, Yu QH (1998). The Improving Effect of Decoction of Coptis and Its Extract on Intelligence. Journal of Shenyang Pharmacoeuticel University. 1998, 15 (1): 35~37.
20 Ye FG, Yu QH, Shao L (1998).  Antioxidant Activity of Calculus Boris for Lipid. China Journal of Traditional Chinese Medicine and Pharmacy. 1998, 13 (2): 69.
21 Yu QH, Zhang YF, Shao L (1997). The role of Immune regulation of Chinese Medicine. Medical Journal of Liaoning. 1997, 11(6): 299-301.

专著:
Methods for Reversing Protein Modification: Ubiquitin and SUMO-specific Proteases”.(2017 Taylor & Francis Publications).
专著章节
SENP1-mediated Signaling in Adipocytes and Type-1 Diabetes Progression.
Lan Shao, Tingting Liu,  Haixuan Chen, and Wang Min 


其他主要工作成绩(比如获奖情况):
中山大学附属第一医院  2015高影响因子奖