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    林水宾

    林水宾
    • 科  室:转化医学研究中心
    • 职  称:研究员
    • 导师资格:博士生导师
    • 最高学历:博士
    出诊时间
    周一 周二 周三 周四 周五 周六 周日
    上午
    下午
    晚上
    (注:出诊信息仅供参考,有可能随时更新,以门诊公布为准。)

    医疗/科研特长

    长期从事RNA表观遗传学、肿瘤和干细胞等方向的研究,从肿瘤的致病机理,干细胞分化调控入手,开展新型肿瘤标志物开发,肿瘤治疗新靶点鉴定,小分子药物筛选等方向的转化医学研究。以 (共同) 第一/通讯作者在Nature (2018,共同一作第二位), Molecular Cell (2018, 2016), Nature Protocols (2019), Nature Communications (2018,共同通讯), Nature Reviews Cancer(2015), RNA Biology(2015), Oncogene(2013), Stem Cells(2013)等国际知名杂志发表论文16篇。论文总被引用次数超过一千次,并申请专利一项。主持国家自然科学基金优秀青年项目,面上项目(2),广东省自然科学基金-杰出青年项目以及广州市民生科技攻关计划等多项科研基金。

     

    研究方向:

    1RNA修饰对肿瘤和干细胞的调控功能和相关机理

    2)发育缺陷疾病的RNA表观遗传学研究

    3)新RNA修饰以及相关修饰酶的鉴定和功能研究

     

    主要教育和工作经历:

    2000-2004 学士福建省厦门大学生命科学学院,国家生物科学人才培养基地班

    2004-2007 硕士福建省厦门大学生命科学学院,生物医学科学系

    2007-2012 博士美国佛罗里达大学医学院(College of Medicine, University of Florida, USA

    2012-2017 博士后美国哈佛大学医学院,波士顿儿童医院 (Harvard Medical School, Boston Children's Hospital)

    2017-至今  中山大学附属第一医院转化医学研究中心工作

     


    社会兼职:

    担任美国基因和细胞治疗协会(American Society of Gene & Cell Therapy)会刊 Molecular Therapy (Cell Press 旗下杂志) 副主编(Deputy Editor)。

     

    论著:

    1.      Choe J*, Lin S *, Zhang W, Liu Q, Wang L, Ramirez-Moya J, Du P, Kim W, Tang S, Sliz P, Santisteban P, George RE, Richards WG, Wong KK, Locker N, Slack FJ, Gregory RI. mRNA circularization by METTL3-eIF3h enhances translation. Nature 2018 Sep;561(7724):556-560 *Equal contribution(影响因子: 41.577).

    2.      Lin S*, Liu Q, Jiang YZ, Gregory RI#. Nucleotide resolution profiling of m7G tRNA modification by TRAC-Seq. Nature Protocols. 2019 Nov; 14: 32203242. (影响因子=11.334)

    3.      Lin S *, Liu Q*, Lelyveld VS, Choe J, Szostak JW, Gregory RI. The Mettl1/Wdr4 mediated m7G tRNA methylome is required for normal mRNA translation and embryonic stem cell self-renewal and differentiation. Mol Cell. 2018 Jul 19;71(2):244-255. *Equal contribution(影响因子: 14.248)

    4.      Lin S*, Choe J*, Du P, Triboulet R, Gregory RI. The m6A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells. Mol Cell. 2016 May 5; 62(3):335-345. * Equal Contribution. Highlighted by Mol Cell. 2016 May 5; 62(3):323-324 and Cancer Discov. 2016 May 5 (影响因子: 14.71).

    5.      Wu Y*, Xie L*, Wang M, Xiong Q, Guo Y, Liang Y, Li J, Sheng R, Deng P, Wang Y, Zheng R, Jiang Y, Ye L, Chen Q, Zhou X#, Lin S #, Quan Y#. Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis. Nat Commun 2018. 9:4772. *Equal contribution; #Co-correspondence (影响因子: 12.353).

    6.      Lin X, Chai G, Wu Y, Li J, Chen F, Liu J, Luo G, Tauler J, Du J, Lin S, He C, Wang H. RNA m6A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail. Nat Commun. 2019 May 6;10(1):2065. (影响因子= 11.878)

    7.      Su T*, Zhang Y*, Valerie K, Wang XY, Lin S#, Zhu G#. STING activation in cancer immunotherapy. Theranostics. 2019 Oct 15;9(25):7759-7771. (影响因子= 8.063)

    8.      Zhang Y, Lin S#, Wang XY, Zhu G. Nanovaccines for cancer immunotherapy. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2019 Sep;11(5):e1559. (影响因子= 6.14)

    9.      Lin S, Gregory RI. Identification of small molecule inhibitors of Zcchc11 TUTase activity. RNA Biol. 2015;12(8):792-800. (影响因子: 3.9).

    10.  Lin S, Gregory RI. MicroRNA biogenesis in cancers. Nat Rev Cancer. 2015 Jun;15(6):321-33.(影响因子: 37.15).

    11.  Lin S , Gregory RI. Methyl-transferases modulate RNAs stability in embryonic stem cells. Nat Cell Biol. 2014 Feb;16(2):129-31. (News and Views). (影响因子: 20.06).

    12.  Lin S * , Tian L*, Shen H*, Gu Y, Li JL, Chen Z, Sun X, You MJ, Wu L. DDX5 is a positive regulator of oncogenic NOTCH1 signaling in T cell acute lymphoblastic leukemia. Oncogene.2013 Oct;32(40):4845-53. * Equal Contribution (影响因子: 7.52).

    13.  Lin S , Shen H, Jin B, Gu Y, Chen Z, Cao C, Hu C, Keller C, Pear WS, Wu L. Loss of function of Notch signaling in muscle stem cells results in muscular dystrophy in mice. Stem Cells. 2013 Apr;31(4):823-8. Highlighted in Front Cell Dev Biol. 2015 Feb 18;3:11. (影响因子: 5.60).

    14.  Lin S , Shen H, Li JL, Tang S, Gu Y, Chen Z, Hu C, Rice JC, Lu J, Wu L. Proteomic and functional analyses reveal the chromatin reader SFMBT1's role in regulating epigenetic silencing and the myogenic gene program. J Biol Chem. 2013 Mar 1;288(9):6238-47. (影响因子:4.13).

    15.  Gu Y*, Lin S * , Li JL, Nakagawa H, Chen Z, Jin B, Tian L, Ucar DA, Shen H, Lu J, Hochwald SN,Kaye FJ, Wu L. Altered LKB1/CREB-regulated transcription co-activator (CRTC) signaling axis promotes esophageal cancer cell migration and invasion. Oncogene. 2012 Jan 26;31(4):469-79. * Equal Contribution (影响因子: 7.52).

    16.  Chen Z, Lin S, Li JL, Ni W, Guo R, Lu J, Kaye FJ, Wu L. CRTC1-MAML2 fusion-induced lncRNA LINC00473 expression maintains the growth and survival of human mucoepidermoid carcinoma cells. Oncogene. Jan 2018 (影响因子: 7.52).

    17.  Cinkornpumin J, Roos M, Nguyen L, Liu X, Gaeta X, Lin S, Chan DN, Liu A, Gregory RI, Jung M, Chute J, Zhu H, Lowry WE. A small molecule screen to identify regulators of let-7 targets. Sci Rep. 2017 Nov 21;7(1):15973. (影响因子: 4.26).

    18.  Chen Z, Li JL, Lin S , Cao C, Gimbrone NT, Yang, R, Fu DA, Carper M, Haura E, Schabath MB,Lu J, Amelio AL, Cress D, Kaye F, Wu L. cAMP/CREB-regulated LINC00473: potential biomarker and therapeutic target for LKB1-inactivated cancer. J Clin Invest. 2016 May 126 (6). (影响因子: 12.78).

    19.   Thornton JE, Du P, Jing L, Sjekloca L, Lin S , Grossi E, Sliz P, Zon LI, and Gregory RI. Sequence-specific mono-uridylation of mature miRNAs by Zcchc6 and Zcchc11. Nucl Acids Res. 2014 Oct;42(18):11777-91. (影响因子: 10.16).

    20.  Chen Z, Chen J, Gu Y, Hu C, Li JL, Lin S , Shen H, Cao C, Gao R, Li J, Ha PK, Kaye FJ, GriffinJD, Wu L. Aberrantly activated AREG-EGFR signaling is required for the growth and survival of CRTC1-MAML2 fusion-positive mucoepidermoid carcinoma cells. Oncogene. 2014 Jul17;33(29):3869-77. (影响因子: 7.52).

    21.  Tang M*, Shen H*, Jin Y, Lin T, Cai Q, Pinard M, Biswas S, Quyen, T, Li G, Shenoy A, Tongdee E, Lin S , Gu Y, Law B, Zhou L, Mckenna R, Wu L, Lu J. The MBT domain protein SFMBT1 is an integral histone reader subunit of the LSD1 demethylase complex for chromatin association and epithelial-to-mesenchymal transition. J Biol Chem. 2013 Sep 20;288(38):27680-91. * Equal Contribution (影响因子: 4.13).

    22.  Chen Z, Jin G, Lin S , Lin X, Gu Y, Zhu Y, Hu C, Zhang Q, Wu L, Shen H. DNA methyltransferase inhibitor CDA-II inhibits myogenic differentiation. Biochem Biophys Res Commun. 2012 Jun 8;422(3):522-6. (影响因子: 2.47).

    23.  Jin B, Shen H, Lin S , Li JL, Chen Z, Griffin JD, Wu L. The mastermind-like 1 (MAML1) co-activator regulates constitutive NF-kappaB signaling and cell survival. J Biol Chem. 2010 May 7;285(19):14356-65. (影响因子: 4.13).

    24.  Li Z, Ruan L, Lin S , Gittes GK. Clock controls timing of mouse pancreatic differentiation through regulation of Wnt- and Notch-based and cell division components. Biochem Biophys Res Commun. 2007 Aug 3;359(3):491-6. (影响因子: 2.47)

    25.  Tao P, Xu D, Lin S , Chang Y, Ouyang G, Chen Q, Yuan Y, Zhuo X, Luo Q, Li J, Ruan L, Li Q and Li Z. Novel truncation analysis and high efficient detection of mutant midkine in human tumors,cancers and cell lines. Cancer Lett. 2007 Aug 8;253(1):60-7. (影响因子: 6.38).

    26.  Chen Q, Yuan Y, Lin S , Chang Y, Zhuo X, Wei W, Tao P, Ruan L, Li Q, Li Z. Transiently truncated and differentially regulated expression of midkine during mouse embryogenesis. Biochem Biophys Res Commun. 2005 May 20;330(4):1230-6. (影响因子: 2.47).

     

    其他主要工作成绩:

    2013 Damon Runyon-Sohn Pediatric Fellowship Award, Damon Runyon Cancer Research Foundation

    2017 Young Investigator award, Alex's Lemonade Stand Foundation