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    林水宾

    林水宾
    • 科  室:转化医学研究中心
    • 职  称:研究员
    • 导师资格:博士生导师
    • 最高学历:博士
    出诊时间
    周一 周二 周三 周四 周五 周六 周日
    上午
    下午
    晚上
    (注:出诊信息仅供参考,有可能随时更新,以门诊公布为准。)



    医疗/科研特长


    长期从事RNA表观遗传学、肿瘤和干细胞等方向的研究,从肿瘤的致病机理,干细胞分化调控入手,开展新型肿瘤标志物开发,肿瘤治疗新靶点鉴定,小分子药物筛选等方向的转化医学研究。以 (共同) 第一/通讯作者在Nature (2018,共同一作第二位), Molecular Cell (2018, 2016), Nature Communications(2018,共同通讯), Nature Reviews Cancer(2015), RNA Biology(2015),Oncogene(2013), Stem Cells(2013)等国际知名杂志发表论文13篇。论文总被引用次数超过一千次,并申请专利一项。作为课题负责人主持美国著名研究基金会Damon Runyon Cancer Research FoundationAlex's Lemonade Stand Foundation、国家自然科学基金面上项目等多项科研基金。


     


    研究方向:1RNA修饰对肿瘤和干细胞的调控功能和相关机理


    2)发育缺陷疾病的RNA表观遗传学研究


    3)新RNA修饰以及相关修饰酶的鉴定和功能研究


     


    主要教育和工作经历:


    2000-2004 学士 福建省厦门大学生命科学学院,国家生物科学人才培养基地班


    2004-2007 硕士 福建省厦门大学生命科学学院,生物医学科学系


    2007-2012 博士 美国佛罗里达大学医学院(College of Medicine, Universityof Florida, USA


    2012-2017 博士后 美国哈佛大学医学院,波士顿儿童医院 (Harvard MedicalSchool, Boston Children's Hospital)


    2017-至今  中山大学附属第一医院转化医学研究中心工作



    社会兼职:


     


    论著:


    1. ChoeJ*, Lin S *, Zhang W, Liu Q, Wang L,Ramirez-Moya J, Du P, Kim W, Tang S, Sliz P, Santisteban P, George RE, RichardsWG, Wong KK, Locker N, Slack FJ, Gregory RI. mRNA circularization byMETTL3-eIF3h enhances translation. Nature 2018 Sep;561(7724):556-560 *Equalcontribution(影响因子: 41.577).

    2. Lin S*, Liu Q*, Lelyveld VS, Choe J, SzostakJW, Gregory RI. The Mettl1/Wdr4 mediated m7G tRNA methylome is required fornormal mRNA translation and embryonic stem cell self-renewal anddifferentiation. Mol Cell. 2018 Jul 19;71(2):244-255. *Equal contribution(影响因子: 14.248)

    3. WuY*, Xie L*, Wang M, Xiong Q, Guo Y, Liang Y, Li J, Sheng R, Deng P, Wang Y,Zheng R, Jiang Y, Ye L, Chen Q, Zhou X#, Lin S #, QuanY#. Mettl3-mediated m6A RNA methylation regulates the fate of bone marrowmesenchymal stem cells and osteoporosis. Nat Commun 2018. 9:4772. *Equalcontribution; #Co-correspondence (影响因子: 12.353).

    4. Lin S*,Choe J*, Du P, Triboulet R, Gregory RI. The m6A Methyltransferase METTL3Promotes Translation in Human Cancer Cells. Mol Cell. 2016 May 5;62(3):335-345. * Equal Contribution. Highlighted by Mol Cell. 2016 May 5;62(3):323-324 and Cancer Discov. 2016 May 5 (影响因子:14.71).

    5. LinS, Gregory RI. Identification of smallmolecule inhibitors of Zcchc11 TUTase activity. RNA Biol. 2015;12(8):792-800. (影响因子:3.9).

    6. Lin S,Gregory RI. MicroRNA biogenesis in cancers. Nat Rev Cancer. 2015Jun;15(6):321-33.(影响因子: 37.15).

    7. Lin S , Gregory RI.Methyl-transferases modulate RNAs stability in embryonic stem cells. Nat CellBiol. 2014 Feb;16(2):129-31. (News and Views). (影响因子: 20.06).

    8. Lin S * , Tian L*, Shen H*, Gu Y, LiJL, Chen Z, Sun X, You MJ, Wu L. DDX5 is a positive regulator of oncogenicNOTCH1 signaling in T cell acute lymphoblastic leukemia. Oncogene.2013Oct;32(40):4845-53. * Equal Contribution (影响因子: 7.52).

    9. Lin S , Shen H, Jin B, Gu Y, Chen Z,Cao C, Hu C, Keller C, Pear WS, Wu L. Loss of function of Notch signaling inmuscle stem cells results in muscular dystrophy in mice. Stem Cells. 2013Apr;31(4):823-8. Highlighted in Front Cell Dev Biol. 2015 Feb 18;3:11. (影响因子: 5.60).

    10. Lin S , Shen H, Li JL, Tang S, Gu Y,Chen Z, Hu C, Rice JC, Lu J, Wu L. Proteomic and functional analyses reveal thechromatin reader SFMBT1's role in regulating epigenetic silencing and themyogenic gene program. J Biol Chem. 2013 Mar 1;288(9):6238-47. (影响因子:4.13).

    11. Gu Y*, Lin S* , Li JL, Nakagawa H, Chen Z, Jin B, Tian L, Ucar DA, Shen H, Lu J, HochwaldSN,Kaye FJ, Wu L. Altered LKB1/CREB-regulated transcription co-activator (CRTC)signaling axis promotes esophageal cancer cell migration and invasion.Oncogene. 2012 Jan 26;31(4):469-79. * Equal Contribution (影响因子: 7.52).

    12. ChenZ, Lin S, Li JL, Ni W, Guo R,Lu J, Kaye FJ, Wu L. CRTC1-MAML2 fusion-induced lncRNA LINC00473 expressionmaintains the growth and survival of human mucoepidermoid carcinoma cells. Oncogene.Jan 2018 (影响因子: 7.52).

    13. CinkornpuminJ, Roos M, Nguyen L, Liu X, Gaeta X, LinS, Chan DN, Liu A, Gregory RI, Jung M, Chute J, Zhu H, Lowry WE. Asmall molecule screen to identify regulators of let-7 targets. Sci Rep. 2017Nov 21;7(1):15973. (影响因子: 4.26).

    14. ChenZ, Li JL, Lin S , Cao C,Gimbrone NT, Yang, R, Fu DA, Carper M, Haura E, Schabath MB,Lu J, Amelio AL,Cress D, Kaye F, Wu L. cAMP/CREB-regulated LINC00473: potential biomarker andtherapeutic target for LKB1-inactivated cancer. J Clin Invest. 2016 May 126(6). (影响因子:12.78).

    15. Thornton JE, Du P, Jing L, Sjekloca L, Lin S , Grossi E, Sliz P, ZonLI, and Gregory RI. Sequence-specific mono-uridylation of mature miRNAs byZcchc6 and Zcchc11. Nucl Acids Res. 2014 Oct;42(18):11777-91. (影响因子: 10.16).

    16. Chen Z, Chen J, Gu Y, Hu C, Li JL, Lin S , Shen H, Cao C, Gao R, LiJ, Ha PK, Kaye FJ, GriffinJD, Wu L. Aberrantly activated AREG-EGFR signaling isrequired for the growth and survival of CRTC1-MAML2 fusion-positivemucoepidermoid carcinoma cells. Oncogene. 2014 Jul17;33(29):3869-77. (影响因子: 7.52).

    17. Tang M*, Shen H*, Jin Y, Lin T, Cai Q, Pinard M,Biswas S, Quyen, T, Li G, Shenoy A, Tongdee E, Lin S , Gu Y, Law B, Zhou L, Mckenna R, Wu L, Lu J. The MBTdomain protein SFMBT1 is an integral histone reader subunit of the LSD1demethylase complex for chromatin association and epithelial-to-mesenchymaltransition. J Biol Chem. 2013 Sep 20;288(38):27680-91. * Equal Contribution (影响因子: 4.13).

    18. Chen Z, Jin G, LinS , Lin X, Gu Y, Zhu Y, Hu C, Zhang Q, Wu L, Shen H. DNA methyltransferaseinhibitor CDA-II inhibits myogenic differentiation. Biochem Biophys Res Commun.2012 Jun 8;422(3):522-6. (影响因子: 2.47).

    19. Jin B, Shen H, LinS , Li JL, Chen Z, Griffin JD, Wu L. The mastermind-like 1 (MAML1)co-activator regulates constitutive NF-kappaB signaling and cell survival. JBiol Chem. 2010 May 7;285(19):14356-65. (影响因子: 4.13).

    20. Li Z, Ruan L, LinS , Gittes GK. Clock controls timing of mouse pancreaticdifferentiation through regulation of Wnt- and Notch-based and cell divisioncomponents. Biochem Biophys Res Commun. 2007 Aug 3;359(3):491-6. (影响因子: 2.47)

    21. Tao P, Xu D, LinS , Chang Y, Ouyang G, Chen Q, Yuan Y, Zhuo X, Luo Q, Li J, Ruan L, LiQ and Li Z. Novel truncation analysis and high efficient detection of mutantmidkine in human tumors,cancers and cell lines. Cancer Lett. 2007 Aug8;253(1):60-7. (影响因子: 6.38).

    22. Chen Q, Yuan Y, LinS , Chang Y, Zhuo X, Wei W, Tao P, Ruan L, Li Q, Li Z. Transientlytruncated and differentially regulated expression of midkine during mouseembryogenesis. Biochem Biophys Res Commun. 2005 May 20;330(4):1230-6. (影响因子: 2.47).

      专著:

       

      其他主要工作成绩(比如获奖情况):

      2013 DamonRunyon-Sohn Pediatric Fellowship Award, Damon Runyon Cancer Research Foundation

    2017 Young Investigator award, Alex's LemonadeStand Foundation

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