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    学术活动(按姓名排序)
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    中山大学附属第一医院支持计划优秀青年人才学术交流会

    出诊时间
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    (注:出诊信息仅供参考,有可能随时更新,以门诊公布为准。)
    TITLE1Brain Metastases and Glioma Stem Cells — molecular signaling and therapeutic targeting
    主讲人:Dr.Suyun Huang
    TITLE2Translational Gastrointestinal Cancer Research and Targeted Personalized Therapy
    主讲人:Dr.Suyun Huang
    TITLE3Inhibition of FoxM1 Sensitilizes Temozolomide Resistant Glioblastoma Cells by Decreasing the Expression of DNA Damage Repair Gene Rad51
    主讲人:张弩 博士
     
    主持人:张弩 博士
    时 间:2011年8月4日下午3:00-6:00
    地 点:门急诊楼17楼学术厅
     
    欢迎广大师生光临指导
     
    附专家简历:

    Dr.Suyun Huang  

    Primary Appointment
    Associate Professor, Department of Neurosurgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX
    Dual/Joint/Adjunct Appointment
    Associate Professor, Department of Neurosurgery, Baylor College of Medicine, Houston, TX
    The University of Texas M. D. Anderson Cancer Center
    Department of Neurosurgery
    Research Interests:
    • Molecular mechanisms of tumor metastasis
    • Angiogenesis
    • Transcriptional factors
    • Molecular diagnosis and therapy
    My research focuses on the molecular regulation of gene expression that play critical roles in tumor angiogenesis, invasion and metastasis. I am currently investigating the m olecular determinants of brain metastasis (from other organs) and primary brain tumor (glioma). Specifically, I am studying the transcriptional regulation of genes that play critical roles in tumor angiogenesis, invasion and metastasis, e.g., VEGF, bFGF and MMPs. The important role of transcription factors, such as NF- k B , Stat3 and FoxM1, in the regulation the expression of these genes is being studied. The effects of altered activation of these transcription factors on tumor angiogenesis, invasion and metastasis are also being examined on animal models. These studies contributeto better understanding of molecular mechanism of tumor metastasis, and provide insights for development of potential prognostic and therapeutic strategies against metastasis.
    Title:
    Brain Metastases and Glioma Stem Cells — molecular signaling and therapeutic targeting
     
    Dr.Keping Xie
              
    Professor, GI Med Oncology - Research
    The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center
    Department of GI Medical Oncology
    Department of Cancer Biology
    Research Interests:
    • Cancer metastasis
    • Angiogenesis
    • Gene regulation
    • Molecular diagnosis and therapy
    Metastatic pancreatic adenocarcinoma is a lethal disease. Using molecular and cell biology techniques coupled with human specimens and animal models, we have continued to investigate the molecular mechanisms governing pancreatic cancer metastasis, with a focus on the regulation and interplay of multiple transcription factors such as AP-1, NF-kB, Sp1, and Stat3. Abnormal activation of these factors leads to aberrant expression of multiple metastasis-related proteins such as inducible nitric oxide synthase (iNOS), interkeukin-8 (IL-8) and vascular endothelial growth factor (VEGF), which confer a tremendous growth advantage to metastatic pancreatic cancer cells. There are two major pathways leading to overactivation of these transcription factors. One mechanism relates to the genetic mutations of oncogenes and/or suppressor genes, such as Ras and p53, resulting in constitutive activation of the transcription factors.
    Title:
    Translational Gastrointestinal Cancer Research and Targeted Personalized Therapy