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    杨蜀岚

    杨蜀岚
    • 科  室:
    • 职  称:研究员
    • 导师资格:博士生导师
    • 最高学历:博士研究生
    出诊时间
    周一 周二 周三 周四 周五 周六 周日
    上午
    下午
    晚上
    (注:出诊信息仅供参考,有可能随时更新,以门诊公布为准。)

    医疗/科研特长

       应用斑马鱼为模式生物研究与人类重要疾病相关基因的功能。团队目前已构建并获得多个重要人类疾病相关基因的斑马鱼敲除品系以及诱导型过表达转基因斑马鱼品系,并对其生物学功能进行了初步研究,结合临床样本和其他生物模型,进一步探索这些基因的异常表达导致疾病发生的分子机制。

    研究方向:人类疾病相关易感基因的致病机制研究


    主要教育和工作经历:

    200012月获农学博士学位。2001年到2011年期间,先后在新加坡分子和细胞生物学研究院(IMCB)从事博士后研究和担任研究员、资深研究员工作,主要以模式生物拟南芥、斑马鱼为研究对象,研究机体器官发育的分子机理。201112月,作为中山大学“百人计划”引进人才到本院工作,建立了斑马鱼疾病模式动物公共平台,开展人类疾病相关易感基因的致病机制研究,并与其他相关科室合作,共同促进基础与临床相结合的转化医学研究。


    社会兼职:

     

    论著:

    1.      TongFang#,Zhang Mingming, Guo Xiaoling, Hongshun Shi, Guan Wen , Wang Haihe* and  YangShulan*. Expression patterns ofSH3BGR family members in zebrafish development.DevelopmentGenes and Evolution 2016, 226(4): 287-295.

    2.     Zhang Wenliang#,Shi Hongshun#, Zhang Mingming, Liu Bin, Mao Shuai, Li Li, Tong Fang,Liu Guoliang, Yang Shulan*., and Wang Haihe*. Poly C bindingprotein 1 represses autophagy through downregulation of LC3B to promote tumorcell apoptosis in starvation. International Journal of Biochemistry and CellBiology. 2016, 73: 127-136.

    3.     Li Li#, ShiHongshun#, Zhang Mingming, Guo Xiaoling, Tong Fang, Zhang Wenliang,Zhou Junyi, Wang Haihe*, Yang Shulan*.Upregulation of metastasis-associated PRL-3 initiates chordoma in zebrafish.International Journal of Oncology, 2016, 48(4):1541-1552.

    4.     QuShuang#,  Liu Bin, Guo Xiaoling,Shi Hongshun,Zhou Meifeng, Li Li,  Yang Shulan,  Tong Xiuzhen*, and Wang,Haihe*.Independent oncogenic and therapeuticsignificance of phosphatase PRL-3 in FLT3-ITD–negative acute myeloid leukemiaCancer.2014, 120(14): 2130-2141.

    5.      Yang Shu-Lan#,, Aw Sharon Siqi, ChangQingchang, Korzh Svetlana, Korzh Vladimir*,and Peng Jinrong*. Depletion of Bhmt elevatessonic hedgehog transcript levels to promote pancreatic islet development inzebrafish, Endocrinology, 2011: 152(12):4706-4717.

    6.     Korzh Svetlana, Winata Cecilia L, Zheng Weiling, Yang Shulan, Ao Yin, Philip Ingham,Zhiyuan Gong*.  The interaction of epithelial Ihha andmesenchymal Fgf10 in zebrafish esophageal and swimbladder development.Developmental Biology, 2011,359262276.

    7.     Ma Hongli#, Zhang Shubiao, Ji Lan, ZhuHongbo, Yang Shulan, Fang Xuanjunand Yang Rencui. Mapping and in silico isolation of the EUI1 gene controllingupper internode elongation in rice. Plant Molecular Biology, 2006, 60: 87-94

    8.     Yang Shu-Lan#, Puah Ching San, Xie Li-Fen, Jiang Lixi, ZhangXue-Qin, Chen Li-Qun, Ye De. Over-expression of TPD1 alters the cell fates inthe arabidopsis carpel and tapetum via genetic Interaction with EMS1/EXS. PlantPhysiology, 2005, 139: 186-191.

    9.     Jiang Li-Xi#,  Yang Shu-Lan#, Xie Li-Fen, Puah Ching San,Yang Wei-Cai, Sundaresan Venkatesan and Ye De. VANGUARD1  encodes a pectin methylesterase  that enhances pollen tube growth in theArabidopsis style and transmitting tract. Plant Cell, 2005, 17: 584-596. (Facultyof 1000 推荐).

    10.  Yang Shu-Lan#, Xie Li-Fen, Mao Hui-Zhu, PuahCS, Yang Wei Cai, Jiang Lix, Ye De. 2003. Tapetum determinant 1 gene isrequired for cell specialization in the Arabidopsis anther. Plant Cell, 15:2792-2804. (Faculty of 1000推荐).

     

    专著:

     

    其他主要工作成绩(比如获奖情况):