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    题目:GABRB2 in psychiatric disorders and human behavior: genetics, gene expression and clinical correlations                                      
    主讲人:Dr. CHEN, Jianhuan  
    Department of Biochemistry & Applied Genomics Center
    Fok Ying Tung Graduate School
    The Hong Kong University of Science & Technology                                             
     中山大学附属第一医院神经科研究员 博士生导师
    主讲人简介:Jianhuan Chen,Male,27 years old.
    2004–2009,PhD. In biochemistry (molecular medicine)
    Department of Biochemistry and Applied Genomics Center
       The Hong Kong University of Science & Technology (HKUST)
    2000–2004,B.S,major in biotechnology,minor in computer science
    Department of Biochemistry, School of Life Sciences
    Sun Yat-sen University (SYSU)
    Research interest:
    His research interest is related to molecular biology, genomics, system biology and bioinformatics. His research focuses on molecular mechanism and the application of molecular biology, bioinformatics and genomics methods in study on biological system.
    内容简介The schizophrenia- (SCZ-) associated GABAA receptor b2 subunit gene GABRB2 was found to be associated bipolar disorder (BPD) and human behavior such as decision making. The present study examined the functional mechanism of GABRB2 in the two major psychotic disorders. Association of GABRB2 with both SCZ and BPD was compared; GABRB2 expression was quantified in post-mortem brains; and clinical parameters were analyzed for genotypic correlations. Although weaker than its association with SCZ, significant association of GABRB2 with BPD was found in both German and Chinese, especially for the haplotypes rs1816071-rs187269 and rs1816072-rs187269 for which the M-M variants showed higher frequency in disease than control. Significant reduction in GABRB2 expression was shown for BPD in a genotype-dependent manner, but to a lesser extent than that reported for SCZ. Moreover, for the homozygous major genotypes of rs1816071, rs1816072 and rs187269, expression increased with time in CON but decreased in SCZ and BPD. The genotypes of these three SNPs were correlated with antipsychotics dosage in SCZ cohorts. And these genetic variations were further found to affecthuman behavior, such as decision making, using our economic model, which thus added to the hypothesis of the orbitofrontal cortex being linked to the incidence of risk aversion. In general, the results highlight the importance of GABRB2 in both disease etiology and human behavior, supporting the suggestion that functional psychosis can beconceptualized as a continuous spectrum of clinical phenotypes rather than as distinct categories.
                                      中山大学附属第一医院 神经科